Cardiovascular disease is a comprehensive manifestation of biochemical, physiological and pathological processes under the interaction of genetic and environmental factors. A large number of epidemiological surveys and clinical observations as well as extensive basic research help us to better explore cardiovascular diseases. In order to study the pathogenesis of human cardiovascular diseases, find effective diagnosis and prevention methods, and screen effective drugs against cardiovascular diseases, experimental pathological models of several common cardiovascular diseases such as myocardial ischemia, myocardial infarction and myocardial injury can be replicated by experimental animals to gain more scientific insights.
Rats are closer to humans than mice in terms of cardiovascular, neurological and drug metabolism. The rat is an important tool for assessing the cardiac electrophysiological effects of experimental drugs and for studying the distribution and action of ion channels in cardiovascular diseases. The rat model can compensate for the shortcomings of large animals (e.g., pigs \ dogs \ sheep, etc.) and small animals (e.g., mice) and is an excellent model for studying cardiovascular diseases, especially stroke and hypertension. There are several strains of rat models that have become ideal for these studies.
Based on Luminex multiplex technology, Creative Proteomics offers rat cardiovascular disease multiplex assays allowing quantitative analysis of multiple analytes from a small number of serum/plasma samples.
Magnetic bead-based Luminex multiplex assay
|Rat||Rat Cardiovascular Disease 4-Plex Panel||Adiponectin, sE-Selectin, sICAM-1, von Willebrand Factor (vWF)||+Inquiry|
|Rat||Rat Cardiovascular Disease 4-Plex Panel||α-2-Macroglobulin (A2M), α1-Acid Glycoprotein (AGP), FibrinogenΔ, Haptoglobin||+Inquiry|
|Rat||Rat Cardiovascular Disease 6-Plex Panel||α1-Acid Glycoprotein (AGP), Albumin, CystatinC, EGF, NGAL/Lipocalin-2, β-2-Microglobulin||+Inquiry|
|Rat||Rat Cardiovascular Disease 7-Plex Panel||Cardiac Troponin I (cTnl), Cardiac Troponin T (cTnT), Creatine Kinase Myscle (CKM), FABP3, Follistatin-like Protein1 (FSTL1), Myosin Light Chain3 (MYL3), TIMP-1||+Inquiry|
|Rat||Rat Cardiovascular Disease 8-Plex Panel||Calbindin, Clusterin, GSTα, IP-10/CXCL10, KIM-1, Osteopontin (OPN), TIMP-1, VEGF-A||+Inquiry|
|Rat||Rat Cardiovascular Disease 9-Plex Panel||Caveolin-1, Connective Tissue Growth Factor (CTGF), GROα/KC/CINC-1/CXCL1, IL-6, MCP-1/CCL2, PAI-1(total), TIMP-1, TNFα, VEGF-A||+Inquiry|
- 96-well plate design for batch detection of multiplexed factors up to 80 samples
- High sensitivity, as low as pg/mL
- Multi-factor assays performed with 50 μL liquid sample and 200 μg total protein
- Maximized information in a single sample and cross-analysis allowed between analytes
- Run your assay in just 3-5 hours
- Mass-calibrated standards for consistent results with every new lot of material
- Multiplexed protein assays
- Relative protein expression assays
- Detection of cytokine expression patterns
- Biomarker/key factor screening
- Identification of key factors
- Confirmation of biological processes