IL-17 is secreted by CD4+T cells, and can induce epithelial cells, endothelial cells, and fibroblasts to synthesize and secrete IL-6, IL-8, G-CSF, and PGE2, and promote the expression of ICAM-1. These molecules have different functions in different stages of hematopoiesis, inflammation, and immunity. The interleukin 17 family contains six member ligands (IL-17A ~ IL-17F) and five receptors (IL-17RA ~ IL-17RD and SEF). IL-17 is an inflammatory cytokine produced primarily by activated T cells. Among them, IL-17A has strong inflammatory properties, it can promote the local production of chemokines and stimulate the production of IL-6 and PGE-2.Besides, it can also enhance local inflammation and induce intercellular adhesion molecules on the cell surface (intercellular adhesion molecules, ICAM), which drives the response of T cells. IL-17E also has strong pro-inflammatory effects in vitro and in vivo. Other new members of the IL-17 family have distinctly different expression forms, and therefore may have different biological effects.

Mechanism and Function

IL-17 achieves its own biological effects through signal transduction. Among them, the IL-17RA and IL-17RC complexes mediate the response of cells to IL-17A and IL-17F. The complex of IL-17RA and IL-17RB mediates the response of cells to IL-17E / IL-25. First, the IL-17 receptor recruits Act1 as an adaptor for downstream signaling. Transcription factor NF-κB activator 1 (Act1) is a bridge molecule between IL-17RA and TNF receptor-related factor 6 (TRAF6). Later, TRAF6 also became a medium for IL-17A to activate NF-κB and JNK. Finally, activation NF-κB, activates the expression of certain specific genes. But in fact, no matter from the signal level, promoter activity, and transcription level of the IL-17 target gene, IL-17A's ability to activate NF-κB alone is very weak. Although IL-17 can only weakly activate downstream signals and gene expression, it can regulate mRNA stability and cooperate with other cytokines, thereby amplifying the response of target cells to IL-17.

In addition to the TRAF6 / NF-κB pathway, IL-17 is also involved in the MAPK pathway. IL-17A activates all three members of MAPKs (mitogen-activated protein kinases), namely extracellular signal-regulated kinases (ERK1 and ERK2) p44 and p42, Jun protein N-terminal kinase (JNK), and p38.In human mononuclear leukemia cell line U937, IL-17A induces tyrosine phosphorylation of Janus kinase (JAN) and certain members of the signal transduction and transcriptional activator protein (STAT) pathway, including Tyk2, JAK1, 2 And 3, STAT1, 2, 3 and 4, JA K / STAT pathway.As far as the function of IL-17 is concerned, on the one hand, it can play a key role in protecting the host from infection, on the other hand, it also helps to treat tumors. In addition, it also has a role in mediating the balance between infection and autoimmunity.

IL-17 Detection Service Fig 1. Mechanism of Signaling

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We mainly provide the Luminex cytokine detection platform. Luminex uses fluorescently encoded microspheres with specific antibodies to different target molecules. The different microspheres can be combined freely to a certain extent so that up to 100 analytes can be tested multiple times simultaneously in a single experiment.

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IL-17 Detection Service

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  1. Yao Z , Painter S L , et al. Human IL-17: A novel cytokine derived from T cells. The Journal of Immunology, 1996, 155(12):5483-5486.
  2. Moseley T A , Haudenschild D R, et al. Interleukin-17 family and IL-17 receptors. Cytokine & Growth Factor Reviews, 2003, 14(2):155-174.
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