Based on Luminex technology platform, Creative Proteomics provides analysis services for key targets of TNF cell signaling pathway.
Tumor necrosis factor (TNF) is a cytokine produced naturally by macrophages in response to bacterial infection or other immune sources. Mainly produced by activated monocytes/macrophages, it can kill and inhibit tumor cells, promote neutrophil phagocytosis, fight infection, cause fever, induce acute protein synthesis in hepatocytes, and promote myeloid leukemia cells to differentiate into macrophages It promotes cell proliferation and differentiation, is an important inflammatory factor, and participates in the pathological damage of certain autoimmune diseases. Tumor necrosis factor (TNF) has a wide range of biological activities, and plays an important role in endotoxin shock, moxibustion, immune regulation, cell proliferation, cytotoxic activity and antiviral activity.
TNF first binds to the extracellular domain of TNF-R1 to cause trimerization of TNF-R1. Trimeric TNF-R1 recruits downstream signaling proteins such as TRADD, FADD, TRAFZ, and RIP through its aggregated intracellular death domain to assemble into a huge TNF-R1 signaling complex. This complex activates the downstream components. Signal transduction pathway, and finally activate the transcription factor NF-KB, JNK kinase, and induce cell apoptosis. Tumor necrosis factor (TNF), as a type of cytokine that can directly cause tumor cell death, works in concert with interferon to kill tumor cells.
We provide Luminex technology for TNF cell signaling pathway analysis.
Luminex technology is a multifunctional liquid phase analysis platform developed on the basis of colored microspheres, laser technology, applied fluidics and high-speed digital signal processing technology. The core is to encode polypropylene microspheres or magnetic microspheres with fluorescent dyes. By adjusting the different ratios of the two fluorescent dyes, up to 100 microspheres with different fluorescence spectra can be obtained. Each kind of microspheres is covalently cross-linked. Capture antibodies against specific antigens.
TNF is a cytokine produced naturally by macrophages in response to bacterial infection or other immune sources. Tumor necrosis factor (TNF) cell signaling plays a role in promoting the phagocytosis of neutrophils, resisting infection, causing fever, inducing acute protein synthesis in hepatocytes, promoting the differentiation of myeloid leukemia cells into macrophages, and promoting cell proliferation and differentiation effect.
In addition to Luminex Multiplex Assay, Enzyme-linked immunosorbent assay (ELISA), Flow cytometry (FACS analysis) technology can also be provided to meet other customer needs.
Creative Proteomics has developed a signal pathway target detection platform. We are not limited to providing TNF cell signal path detection services, but can also provide other signal path detection services. If you want to detect other targets, please contact us and we will customize the service for you. Look forward to working with you.