Crab-eating macaques are non-human primates (NHP) commonly used in biomedical research. Adult crab-eating macaques have a body length of about 40-47 cm and a tail length of 50-60 cm. Male crab-eating macaques weigh 5-7 kg, and females weigh about 3-4 kg.
Crab-eating macaques are a common animal model for basic research in human biomedicine and drug development, etc. Creative Proteomics has developed a set of microsphere-based Luminex multiplex technologies for the detection of cytokines, chemokines and other protein biomarkers in crab-eating macaques. It can also facilitate nutrition and disease-related studies in crab-eating macaques.
Our services offer the advantage of speed and sensitivity, allowing simultaneous analysis of multiple targets such as T-cell subsets, immunoglobulins, cytokines and complement in crab-eating macaques, improving the efficiency of your research.
The table below shows the types of crab-eating macaque Luminex protein analysis. You can choose from a variety of specifications as needed.
|Crab-Eating Macaque||Adipokines/Obesity||7-Plex Panel||ICAM-1/CD54, IL-10, TNF-α, IL-1β/IL-1F2, TIMP-1, VEGF, IL-6|
|Angiogenesis||6-Plex Panel||GM-CSF, IL-1β/lL-1F2, TIMP-1, lL-1α/lL-1F1, IL-10, VEGF|
|CD8+ T Cell||8-Plex Panel||GM-CSF, IL-4, IL-13, lFN-γ, IL-6, TNF-α, IL-2, IL-10|
|Cardiovascular Disease||11-Plex Panel||ICAM-1/CD54, IL-4, TIMP-1, IFN-γ, IL-6, TNF-α, lL-1β/IL-1F2, IL-10, VEGF, IL-2, L-Selectin/CD62L|
|Inflammatory Factors||6-Plex Panel||IFN-γ, IL-4, IL-10, IL-2, IL-6, TNF-α|
|Tumor Biomarkers||8-Plex Panel||GM-CSF, IL-6, TNF-α, ICAM-1/CD54, IL-18/I1L-1F4, VEGF, IL-2, TIMP-1|
|Th17||9-Plex Panel||GM-CSF, IL-2, IL-10, IFN-γ, IL-4, IL-13, IL-1β/lL-1F2, IL-6, TNF-α|
|Soluble Receptors||3-Plex Panel||ICAM-1/CD54, L-Selectin/CD62L, TIMP-1|
|Kidney Biomarkers||5-Plex Panel||IL-6, IL-18/1L-1F4, VEGF, IL-10, TNF-α|
Magnetic bead-based Luminex multiplex assay
Advantages of Crab-Eating Macaque Luminex Multiplex Platform
- High throughput and high speed: The analysis fluorescence speed can reach up to 5000~15000 pcs/s. It can perform real-time, qualitative and quantitative analysis of many different target molecules in the same sample at the same time in less than 3h.
- High sensitivity: The detection range can reach 3~5 orders of magnitude, and the lowest detection concentration can reach 0.1 pg/mL.
- High specificity and accuracy: homogeneous immunoassay is used without washing, which reduces the error of experimental results caused by washing during operation. Flow laser technology is used in the assay to detect each microsphere, preventing interference from heteroantigens (antibodies) in the specimen.
- Small amount of specimens: The simultaneous detection of multiple indicators in the same reaction well significantly reduces the amount of specimens compared to other methods, making it suitable for the detection of rare specimens.
Why Use Crab-Eating Macaques?
Crab-eating macaques are often used as ideal models for basic research in disease pathology, vaccine development, immunology and cardiology due to their 90-93% genetic similarity to humans. Crab-eating macaques are also used in the pharmaceutical industry for toxicology and efficacy studies in drug development. However, experiments in crab-eating macaques require a comprehensive consideration of the drug's mechanism in order to make a final determination on whether or not to perform on crab-eating macaques. For example, the lack of HIV progression in crab-eating macaques has led to failure in HIV modeling. If anti-CD28 agonist antibodies are developed, crab macaques are poorer models because their CD4+ T cells do not express CD28. therefore, the high doses of antibodies used in toxicology studies have no effect on crab monkeys.