Description

Cardiovascular disease, particularly atherosclerotic vascular disease, is the leading cause of death worldwide. It is widely recognized that inflammatory mechanisms play a crucial role in the onset, maintenance and progression of vascular disease. There is a strong correlation between inflammatory markers and the prognosis of acute and chronic coronary artery disease. In addition, many studies have shown that obesity and diabetes are associated with cardiovascular risk factors.

Creative Proteomics offers the Luminex Human Cardiovascular Disease 6-plex/8-plex/10-plex/11-plex/12-plex Panel for quantifying human cardiovascular disease-related factors in serum, plasma, tissue culture supernatants and cultured cells. These panels contain known human cardiovascular and inflammatory markers, as well as candidate proteins with equal potential as markers of cardiovascular disease, and help to understand the mechanisms of immune cell activation and the cytokine circuits that underlie disease progression, revealing additional roles for cytokines in cardiovascular disease. Based on Luminex xMAP technology, ideal speed and sensitivity can be achieved for simultaneous quantification of multiple analytes, significantly increasing productivity and saving valuable sample volumes.

Detection Method

Magnetic bead-based Luminex multiplex assay

Species

Human

Transportation

Wet ice

Analytes Detected

SpeciesSpecificationProtein TargetsPrice
HumanHuman Cardiovascular Disease 6-plex PanelApoAI, ApoA II, ApoB, ApoC I, ApoC III, ApoE+Inquiry
HumanHuman Cardiovascular Disease 8-plex PaneldPAPP-A, Follistatin (FST), Pentraxin-3 (PTX3), sCD31/sPECAM-1, sE-Selectin, Thrombomodulin, Tissue Factor (TF), TroponinT (TnT)+Inquiry
HumanHuman Cardiovascular Disease 10-plex PanelADAMTS13, D-dimer, GDF-15, Myeloperoxidase (MPO), Myoglobin, NGALLipocalin-2, SerumAmyloidA.sICAM-1, sP-Selectin, sVCAM-1+Inquiry
HumanHuman Cardiovascular Disease 11-plex PanelAdipsin, CRP, FetuinA, Fibrinogen, Haptoglobin, Platelet Factor4 (PF4), Senum AmyloidP, sL-Selectin, vonWillebrand Factor (vWF), α1-AcidGlycoprotein (AGP), α-2-MacroglobulinF+Inquiry
HumanHuman Cardiovascular Disease 12-plex PanelCK-MB, CXCL16, Endocan (ESM-1), FABP3, FABP4, LIGHT, LIX/CXCL6/GCP-2, NP, NTproBNP, Oncostatin (OSM), Placental Growth Factor (PLGF), TroponinI (TnI)+Inquiry

Service Features

  • 96-well plate design for batch detection of multiplexed factors up to 80 samples
  • High sensitivity, as low as pg/mL
  • Multi-factor assays performed with 50 μL liquid sample and 200 μg total protein
  • Suitable for serum/plasma, culture supernatants, cells, tissue lysates, some panels can also be validated with breast milk, saliva and/or urine samples
  • No batch-to-batch errors
  • Maximized information in a single sample and cross-analysis allowed between analytes
  • Run your assay in just 3-5 hours
  • Mass-calibrated standards for consistent results with every new lot of material

Service Features

Suggested Application

  • Multiplexed protein assays
  • Relative protein expression assays
  • Detection of cytokine expression patterns
  • Biomarker/key factor screening
  • Identification of key factors
  • Confirmation of biological processes
* For Research Use Only. Do Not use in diagnostic or therapeutic procedures.

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