Description
Diabetes mellitus is a metabolic disease characterized by hyperglycemia. Insulin deficiency and/or insulin resistance in the body can lead to a chronic increase in blood glucose, which in turn leads to severe damage and dysfunction of the eyes, kidneys, heart, blood vessels, nerves and other organs.
Type I diabetes (T1D) is a T cell-mediated inflammatory autoimmune disease characterized by specific damage to pancreatic beta cells. Macrophages, lymphocytes and other cytokines produced by infiltrating pancreatic islets, such as IL-1β, TNF α and interferon α, and interferon γ tumor necrosis factor IL-2, regulate the activation and population ratio of T cells through defective apoptosis/necrosis of pancreatic β cells and insulin secretion, as well as modulate the immune recognition and killing of β cells by T cells. Some cytokines such as fibroblast factor and adipocytokine are associated with diabetes. Dysfunction of adipocytes may affect the development of diabetes mellitus. Adipose tissue is not only a tissue for storing fat and regulating lipid metabolism, but also the largest immune function organ, and adipocytes may influence immune function by secreting cytokines.
Creative Proteomics offers a Human Diabetes 15 plex/25 plex Panel based on Luminex xMAP technology, which allows simultaneous quantification of cytokines, proteins associated with diabetic disease and provides higher sensitivity and wider detection range.
Detection Method
Magnetic bead-based Luminex multiplex assay
Species
Human
Analytes Detected
| Species | Specification | Protein Targets | Price |
|---|---|---|---|
| Human | Human Diabetes Cytokine 4-plex Panel | C-Peptode, GLP-1(active), GLP-1, Insulin, Leptin | +Inquiry |
| Human | Human Diabetes Cytokine 9-plex Panel | C-peptide, ghrelin, GIP, GLP-1, insulin, leptin, PAI-1 (total), resistin, visfatin | +Inquiry |
Service Features
- 96-well plate design for batch detection of multiplexed factors up to 80 samples
- High sensitivity, as low as pg/mL
- Multi-factor assays performed with 50 μL liquid sample and 200 μg total protein
- Suitable for serum/plasma, culture supernatants, cells, tissue lysates
- Maximized information in a single sample and cross-analysis allowed between analytes
- Run your assay in just 3-5 hours
- Mass-calibrated standards for consistent results with every new lot of material
Suggested Application
- Multiplexed protein assays
- Relative protein expression assays
- Detection of cytokine expression patterns
- Biomarker screening
- Identification of key factors
- Confirmation of biological processes
