Leptin signaling pathway

Based on Luminex technology platform, Creative Proteomics provides analysis services for key targets of leptin signaling pathway.

Lipocalin-2(LCN2) Signaling Pathway Detection Service(Brennan AM, et al.2019)Leptin is a secreted protein encoded by the ob gene located on human chromosome (7q 31. 3) and exerts its physiological functions by binding to the leptin receptor. Leptin is a pleiotropic hormone that can participate in the proliferative and anti-apoptotic effects of several systems simultaneously. Previous studies have suggested that leptin can reduce appetite and body weight, regulate fat deposition and energy balance, regulate neuroendocrine effects, and participate in the immune response of the body. Recent studies have found that leptin plays a role in promoting tumor cell proliferation and metastasis by mediating certain intracellular signaling pathways.

The leptin signaling pathway and its mediated signaling pathways have a role in promoting tumor cell proliferation and metastasis. With the in-depth study of leptin and its mediated signal transduction pathway, we will explore its intrinsic connection with tumor development and seek effective chemical or genetic drugs to inhibit or cut off the leptin-mediated signaling pathway, which will lay the experimental foundation for tumor prevention and control of tumor development.

Leptin is a hormone produced in fat cells that affects the brain and some other peripheral tissues. It plays a key role in the regulation of endocrine function and control of energy expenditure. In addition to adipose tissue, the leptin signaling pathway has regulatory roles in other tissues including placenta, ovary, skeletal muscle, pituitary and lymphatic tissue. Leptin regulates food intake and also plays a key role in energy expenditure, metabolism, neuroendocrine axis and immune function.

Our detectable targets:

PTPVPS34VavCrkIITRAF6MEK6
PROLC3PI3KTBK1IRF9IRSI-4p50
PDHKFIP200mTORAMBRA1IRS1p53
LC3IULKMSK2SH2p38MAPKTRAM
c-MycBaxISGF3RIP1MEK3TRIF
ULK1Grb2CAPp38IRF5IRAK1
PFKVDACTRAF3TRAF5Shp-2ISRE
PHGDHANTRIG-1Gab-1TLR3PKR 
Erk1LDHANFκBIRS2Tak1 
ShcLKB1UYRAGMSK1p65 

Technology platform:

We provide Luminex technology for leptin signaling pathway analysis.

Luminex technology is a multifunctional liquid phase analysis platform, which is developed on the basis of high-speed digital signal processing technology, colored microspheres, applied fluidics and laser technology. The core is the use of fluorescent dyes for encoding. By adjusting the different ratios of different fluorescent dyes, more than 100 microspheres with different fluorescence spectra were obtained. The reactions are carried out on microspheres with different fluorescent codes, such as nucleic acid hybridization, antigen-antibody, enzyme-substrate, ligand-receptor binding reactions. Using laser detection technology, qualitative and quantitative analysis of microsphere encoding and reporting fluorescence.

Advantages of leptin signaling pathway detection:

Advantages of leptin signaling pathway detection

Application of our service:

Creative Proteomics has developed a signal pathway target detection platform. We are not limited to providing leptin signal path detection services, but can also provide other signal path detection services. If you want to detect other targets, please contact us and we will customize the service for you. Look forward to working with you.

References:

  1. Brennan AM, Mantzoros CS, et al. Drug Insight: the role of leptin in human physiology and pathophysiology-emerging clinical pplica-tions. Nat Clin Pract Endocrinol Metab, 2019, 2(6): 318.
  2. Wang W, Yan H, et al. Human leptin triggers prolifera-tion of A549 cells via blocking endoplasmic reticulum stress related apoptosis. Biochemistry, 2018, 78(12): 1333.
* For Research Use Only. Do Not use in diagnostic or therapeutic procedures.

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