Apelin signaling pathway

Based on Luminex technology platform, Creative Proteomics provides analysis services for key targets of apelin signaling pathway.

Apelin Signaling Pathway Detection Service(Kawamata, Y., et al. 2020)Apelin is located on human x chromosome, belongs to the angiotensin I receptor related protein. Apelin/APJ system is widely distributed in the central nervous system and peripheral tissues. Apelin is not only a vasoactive peptide, but also an adipose-derived hormone and neuromediator that is involved in the pathogenesis of hypertension, atherosclerosis, cardiovascular disease, diabetes, obesity and many other diseases.

Apelin is an endogenous peptide capable of binding to the apelin receptor (APJ), which was originally described as an unprimed G protein-coupled receptor. Apelin and APJ are widely expressed in a variety of tissues and organ systems. They are implicated in different key physiological processes, such as angiogenesis, cardiovascular function, cell proliferation and regulation of energy metabolism. On the other hand, this ligand receptor is also involved in several pathologies including diabetes, obesity, cardiovascular disease and cancer.

Our detectable targets:

ANTVDACVavIRF9IRS1MEK6
LDHABaxTBK1CrkIIIRSI-4p50
LKB1Grb2mTORAMBRA1SH2p53
ShcPDHKMSK2p38TRAF6TRAM
Erk1LC3IISGF3RIP1p38MAPKTRIF
PHGDHPROLC3CAPTRAF5MEK3IRAK1
PFKULKPI3KGab-1IRF5ISRE
ULK1FIP200VPS34IRS2Shp-2PKR 
c-MycTRAF3UYRAGMSK1TLR3 
PTPRIG-1NFκBp65Tak1 

Technology platform:

We provide Luminex technology for apelin signaling pathway analysis.

Luminex technology is a multifunctional liquid phase analysis platform, which is developed on the basis of high-speed digital signal processing technology, colored microspheres, applied fluidics and laser technology. The core is the use of fluorescent dyes for encoding. By adjusting the different ratios of different fluorescent dyes, more than 100 microspheres with different fluorescence spectra were obtained. The reactions are carried out on microspheres with different fluorescent codes, such as nucleic acid hybridization, antigen-antibody, enzyme-substrate, ligand-receptor binding reactions. Using laser detection technology, qualitative and quantitative analysis of microsphere encoding and reporting fluorescence.

Apart from that, flow cytometry (FACS analysis) and enzyme-linked immunosorbent assay (ELISA) technology can also be provided to meet other customer needs.

Advantages of apelin signaling pathway detection:

Advantages of apelin signaling pathway detection

Application of our service:

References:

  1. Cheng B, Chen J, et al. Neuroprotection of apelin and its signaling pathway. Peptides, 2019, 37(1):171-173.
  2. Kawamata, Y., et al. Molecular properties of apelin: tissue distribution and receptor binding. Biochim Biophys Acta, 2020, 1538(2-3): 162-171.
* For Research Use Only. Do Not use in diagnostic or therapeutic procedures.

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