Description
Cytokines mediate communication between cells and are involved in the complex behavior of cells. Cytokines can influence host behavior even in the absence of infection. There are various neurological diseases, among which depression, Alzheimer's disease, epilepsy, and Parkinson's disease are more common. Studying the interactions between the immune system and the nervous system in diseases can contribute to the progress of scientific research.
Neuroinflammation includes the biochemical and cellular responses of the nervous system to injury, infection, or neurodegenerative disease. Aging, metabolic diseases and viral infections are major sources of inflammation that can affect blood vessels and neurons and lead to neurodegenerative diseases, such as SVD, small vessel disease. Usually, neuroinflammation occurs in response to CNS injury, infection, stimulation by toxins or in response to autoimmunity. Transient neuroinflammatory signaling plays a protective role during development and tissue repair after injury, while chronic neuroinflammation is associated with the progression of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and multiple sclerosis.
Creative Proteomics offers several optional Luminex Human Neurological Disorders Biomarker Panels to study cytokines and other marker proteins in serum, plasma and cell supernatants. Based on the Luminex xMAP technology, higher sensitivity and a wider range of assays are achieved, allowing simultaneous quantification of multiple analytes.
Detection Method
Magnetic bead-based Luminex multiplex assay
Species
Human
Analytes Detected
| Species | Specification | Protein Targets | Price |
|---|---|---|---|
| Human | Human Neurodegenerative Disorders Biomarker 5-plex Panel | Aβ1-40, Aβ1-42, GDNF, S100B, sRAGE | +Inquiry |
| Human | Human Neurodegenerative Disorders Biomarker 6-plex Panel | α-2-Antitrypsin, Complement C4, CRP, MIP-4/PARC, Serum Amyloid P (SAP), PEDF | +Inquiry |
| Human | Human Neurodegenerative Disorders Biomarker 7-plex Panel | α-2-Macroglobulin, ApoA I, ApoC III, ApoE, Complement C3, Complement factor H (CFH), Prealbumin/Transthyretin (TTR) | +Inquiry |
| Human | Human Neurodegenerative Disorders Biomarker 10-plex Panel | BDNF, CathepsinD, Myeloperoxidase (MPO), PAI-1 (total), PDGF-AA, PDGF-AB/BB, RANTES/CCL5, sICAM-1, sNCAM, sVCAM-1 | +Inquiry |
| Human | Human Neurological Disorders Biomarker 9-plex Panel | Ceruloplasmin (CP), Haptoglobin (HP), Serum Amyloid P, α-1-AcidGlycoprotein (AGP) | +Inquiry |
| Human | Human Neurological Disorders Biomarker 11-plex Panel | Angiotensinogen (AGT), Contactin-1, FetuinA, Kallikrein-6, Osteopontin (OPN), Soluble Superoxide Dismutase1 (sSOD1), Soluble Superoxide Dismutase2 (sSOD2) | +Inquiry |
| Human | Human Neuropeptide 6-plex Panel | Neurotensin, OrexinA, Oxytocin, SubstanceP, α-MSH, β-Endorphin | +Inquiry |
Service Features
- 96-well plate design for batch detection of multiplexed factors up to 80 samples
- High sensitivity, as low as pg/mL
- Multi-factor assays performed with 50 μL liquid sample and 200 μg total protein
- Suitable for serum/plasma, culture supernatants, cells, tissue lysates
- Maximized information in a single sample and cross-analysis allowed between analytes
- Run your assay in just 3-5 hours
- Mass-calibrated standards for consistent results with every new lot of material
Application of Neurological Disorders Biomarker Panel
- Multiplexed protein assays
- Relative protein expression assays
- Detection of cytokine expression patterns
- Biomarker screening
- Identification of key factors
- Confirmation of biological processes
